The Borgia family becomes the most powerful and influential family of the Italian Renaissance when the patriarch Rodrigo Borgia becomes Pope Alexander VI.

After exacting vicious punishment on all those who opposed them, the Borgias are at the apex of their power and influence. With the world around them embroiled in war and turmoil, the original crime family will continue to exploit allies, silence critics, and solidify legacies. But this time, the seemingly unbreakable bonds of blood will be tested like never before, as the house notoriously united against the world becomes divided against itself.

In season five, Dexter goes from happily married husband to guilt-ridden single dad. How will it affect his ability to maintain an average-guy facade while satisfying his need to kill?

The Manhattan criminal justice team tries not to let departmental shake-ups impact their abilities to pursue the riveting cases that have shocked the city. Detective Joe Fontana and ADA Alexandra Borgia bring their expertise to grim crimes regarding fake flu vaccines and con men, while ADA Serena Southerlyn exits after her strong opinions put her at odds with her colleagues in the death of a controversial rap producer.

Facing writer's block, the maturation of his teenage daughter, and the marriage of his ex-girlfriend, a novelist indulges in addictions to sex, drugs, and booze.